Zymax contains three fungal proteolytic enzyme systems [including a protease with DPPIV activity, a protease with PEP activity, an aspartic protease (pepsin type)], a cysteine protease (bromelain), amylase, lipase & lactase (tilactase).

It is well known that proline rich dietary proteins such as casein in bovine milk & gluten in cereals resist proteolytic degradation in the human GIT. As a result proline rich fragments can build up & may lead to undesirable effects in specific groups of individuals.Short chain proline rich bio-active called exorphins such as casomorphins produced from A1 casein & gluteomorphins from gluten, display potent opioid activities. An accumulation of these exorphins in the ENS & CNS may be a contributing factor with some individuals presenting with fatigue, confusion & mood disorders.Oral supplementation with proline specific endo-protease & exo-protease can assist in removing exorphins. Two proline specific protease of interest are PEP & DPPIV both identified & assayed from two distinct fungal proteolytic enzyme systems produced by the controlled fermentation of non-genetically modified strains of non pathogenic aspergillus oryzae.